High-resolution x-ray 3D imaging of bone micro-structure

Osteoporosis impact on public health is sharply increasing justifying a significant effort to diagnose,
reat and understand this disease. Bones have been imaged with x-rays for almost a century and the
basic technology for clinical image is well established, but with the recent development of large scale
synchrotron light sources and high-end microfiches x-ray generators, imaging of the intricate bone inner
structure with a few micron resolution become possible. Laser driven betatron x-ray microscope was
built and used to demonstrate the feasibility of high-resolution bone imaging in the Astra-Gemini laser
facility (UK). A sample of femur trabecular bone was imaged from multiple angles and a 3D model of the
bone was built using tomographic techniques to a resolution below 50 micron. This demonstration renew
the interest in the development of compact laser-plasma electron accelerators and its applications. It also
opens prospects for its use in clinic diagnostics in the medium term.